Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus

Horscroft, James A; Murray, Andrew J

doi:10.1186/2046-7648-3-19

Extreme Physiology & Medicine

Table 5 The effects of environmental hypoxia on biomarkers of oxidative phosphorylation in skeletal muscle

From: Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus

First author	Year	Organism	Muscle model	Hypoxia model	p(O ₂ ) _min (kPa)	Duration (d)	Marker	Change
Morash [31]	2013	Mouse	mix	13% O₂	13.1	1	Complex I OXPHOS	=
							Complex II OXPHOS	=
							Complex IV OXPHOS	=
Magalhaes [38]	2005	Mouse	mix	8,500 m	7.4	2	Complex II OXPHOS	↓
Pastoris [29]	1995	Rat	sol	5,860 m	10.1	3	Complex III activity	=
							Complex IV activity	=
Pastoris [29]	1995	Rat	gnm	5,860 m	10.1	3	Complex III activity	=
							Complex IV activity	↓
Morash [31]	2013	Mouse	mix	13% O₂	13.1	7	Complex I OXPHOS	=
							Complex II OXPHOS	=
							Complex IV OXPHOS	=
Vigano [16]	2008	Human	vl	4,559 m	12.4	8	Complex III levels	↓
							Complex V levels	↓
							ETF levels	↓
Chaillou [14]	2013	Rat	pla	5,500 m	11.0	9	Complex IV activity	↓
Jacobs	2013a	Human	vl		12.4	10	Complex I OXPHOS	=
							Complex II OXPHOS	=
							Complex I+II OXPHOS	=
De Palma [27]	2007	Rat	gnm	10% O₂	10.1	14	Complex V levels	↓
Daneshrad [42]	2001	Rat	sol	10% O₂	10.1	21	OXPHOS	↑
Beaudry [39]	2010	Mouse	gnm	480 mmHg	13.4	28	Complex IV activity	=
Gamboa [41]	2010	Mouse	gnm	10% O₂	10.1	28	Complex II levels	↓
							Complex IV levels	↓
							Complex V levels	↓
Gamboa [43]	2012	Mouse	mix	10% O₂	10.1	28	Complex IV levels	↓
							Complex V activity	↑
							Complex I OXPHOS	↓
Jacobs [36]	2013b	Human	vl	3,454 m	14.2	28	Complex I OXPHOS	↓
							Complex II OXPHOS	↓
							Complex I+II OXPHOS	↓
							Complex IV activity	=
McClelland [25]	2002	Rat	sol	4,300 m	12.8	56	Complex IV activity	↓
McClelland [25]	2002	Rat	pla	4,300 m	12.8	56	Complex IV activity	↓
McClelland [25]	2002	Rat	gnm	4,300 m	12.8	56	Complex IV activity	=
Chaillou [14]	2013	Rat	pla	5,500 m	11.0	63	Complex IV activity	↓
Levett [18]	2012	Human	vl	8,848 m	7.1	66	Complex I expression	=
							Complex I levels	↓
							Complex II levels	=
							Complex III levels	=
							Complex IV expression	=
							Complex IV levels	↓
							Complex V expression	=
							Complex V levels	↓

↑ Change in biomarker is indicative of an increase in oxidative phosphorylation in hypoxia.
= No change in biomarker in hypoxia.
↓ Change in biomarker is indicative of a decrease in oxidative phosphorylation in hypoxia.
Abbreviations: gnm gastrocnemius, mix mixed skeletal, pla plantaris, sol soleus, vl vastus lateralis.

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ISSN: 2046-7648

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