From: Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus
First author | Year | Organism | Muscle model | Hypoxia model | p(O 2 ) min (kPa) | Duration (d) | Marker | Change |
---|---|---|---|---|---|---|---|---|
Morash [31] | 2013 | Mouse | mix | 13% O2 | 13.1 | 1 | Citrate synthase activity | = |
 |  |  |  |  |  |  | Complex IV OXPHOS | = |
Magalhaes [38] | 2005 | Mouse | mix | 8,500 m | 7.4 | 2 | Complex II OXPHOS | ↓ |
Magalhaes [46] | 2007 | Mouse | mix | 8,500 m | 7.4 | 2 | Bax expression | ↑ |
 |  |  |  |  |  |  | Bcl-2 expression | ↓ |
Pastoris [29] | 1995 | Rat | sol | 5,860Â m | 10.1 | 3 | Complex IV activity | = |
 |  |  |  |  |  |  | Citrate synthase activity | = |
Pastoris [29] | 1995 | Rat | gnm | 5,860 m | 10.1 | 3 | Complex IV activity | ↓ |
 |  |  |  |  |  |  | Citrate synthase activity | ↓ |
Chaillou [14] | 2013 | Rat | pla | 5,500Â m | 11.0 | 3 | BNIP3 expression | = |
 |  |  |  |  |  |  | PGC-1α expression | = |
Morash [31] | 2013 | Mouse | mix | 13% O2 | 13.1 | 7 | Citrate synthase activity | = |
 |  |  |  |  |  |  | Complex IV OXPHOS | = |
Dutta [28] | 2009 | Rat | mix | 349 mmHg | 10.3 | 7 | Citrate synthase activity | ↓ |
Chaillou [14] | 2013 | Rat | pla | 5,500 m | 11.0 | 9 | Complex IV activity | ↓ |
 |  |  |  |  |  |  | Citrate synthase activity | ↓ |
 |  |  |  |  |  |  | PGC-1α expression | ↑ |
 |  |  |  |  |  |  | BNIP3 expression | = |
Jacobs [35] | 2013a | Human | vl | 4,559Â m | 12.4 | 10 | Complex I OXPHOS capacity | = |
 |  |  |  |  |  |  | Complex II OXPHOS capacity | = |
 |  |  |  |  |  |  | Complex I+II OXPHOS capacity | = |
Levett [18] | 2012 | Human | vl | 5,300Â m | 11.3 | 19 | Mitochondrial density | = |
 |  |  |  |  |  |  | PGC-1α levels | = |
Green [19] | 2000 | Human | vl | 6,194Â m | 10.1 | 21 | Citrate synthase activity | = |
Daneshrad [24] | 2000 | Rat | sol | 10% O2 | 10.1 | 21 | Citrate synthase activity | = |
Daneshrad [42] | 2001 | Rat | sol | 10% O2 | 10.1 | 21 | OXPHOS | ↑ |
Beaudry [39] | 2010 | Mouse | gnm | 480Â mmHg | 13.4 | 28 | Complex IV activity | = |
 |  |  |  |  |  |  | Citrate synthase activity | = |
Gamboa [41] | 2010 | Mouse | gnm | 10% O2 | 10.1 | 28 | Mitochondrial density | = |
 |  |  |  |  |  |  | BNIP3 expression | = |
 |  |  |  |  |  |  | Complex IV levels | ↓ |
 |  |  |  |  |  |  | PGC-1α levels | = |
Gamboa [43] | 2012 | Mouse | mix | 10% O2 | 10.1 | 28 | Complex I OXPHOS | ↓ |
Jacobs [36] | 2013b | Human | vl | 3,454 m | 14.2 | 28 | Complex I OXPHOS | ↓ |
 |  |  |  |  |  |  | Complex II OXPHOS | ↓ |
 |  |  |  |  |  |  | Complex I+II OXPHOS | ↓ |
 |  |  |  |  |  |  | Complex IV activity | = |
 |  |  |  |  |  |  | Citrate synthase activity | = |
Galbes [32] | 2008 | Rat | q | 4,000Â m | 13.3 | 35 | Citrate synthase activity | = |
Green [17] | 1989 | Human | vl | 8,848 m | 7.1 | 40 | Citrate synthase activity | ↓ |
MacDougall [44] | 1991 | Human | vl | 8,848Â m | 7.1 | 40 | Mitochondrial density | = |
van Ekeren [47] | 1992 | Rat | edl | 8% O2 | 8.1 | 45 | Mitochondrial density | ↑ |
van Ekeren [47] | 1992 | Rat | sol | 8% O2 | 8.1 | 45 | Mitochondrial density | ↓ |
Hoppeler [45] | 1990 | Human | vl | 5,000 m | 11.7 | 56 | Mitochondrial density | ↓ |
McClelland [25] | 2002 | Rat | sol | 4,300 m | 12.8 | 56 | Complex IV activity | ↓ |
McClelland [25] | 2002 | Rat | gnm | 4,300Â m | 12.8 | 56 | Complex IV activity | = |
McClelland [25] | 2002 | Rat | pla | 4,300 m | 12.8 | 56 | Complex IV activity | ↓ |
Chaillou [14] | 2013 | Rat | pla | 5,500 m | 11.0 | 63 | Complex IV activity | ↓ |
 |  |  |  |  |  |  | Citrate synthase activity | ↓ |
Abdelmalki [23] | 1996 | Rat | sol | 13% O2 | 13.1 | 64 | Citrate synthase activity | = |
Abdelmalki [23] | 1996 | Rat | pla | 13% O2 | 13.1 | 64 | Citrate synthase activity | ↓ |
Abdelmalki [23] | 1996 | Rat | rq | 13% O2 | 13.1 | 64 | Citrate synthase activity | = |
Abdelmalki [23] | 1996 | Rat | wq | 13% O2 | 13.1 | 64 | Citrate synthase activity | = |
Levett [18] | 2012 | Human | vl | 8,848 m | 7.1 | 66 | Mitochondrial density | ↓ |
 |  |  |  |  |  |  | PGC-1α levels | ↓ |
 |  |  |  |  |  |  | PGC-1α expression | = |
Mizuno [33] | 2008 | Human | vl | 5,250Â m | 11.4 | 75 | Citrate synthase activity | = |