From: Frostbite: a practical approach to hospital management
Grade | Description | Benefits vs. risks and burdens | Methodological quality of supporting evidence |
---|---|---|---|
1A | Strong recommendation, high-quality evidence | Benefits clearly outweigh risks and burdens or vice versa | RCTs without important limitations or overwhelming evidence from observational studies |
1B | Strong recommendation, moderate-quality evidence | Benefits clearly outweigh risks and burdens or vice versa | RCTs with important limitations or exceptionally strong evidence from observational studies |
1C | Strong recommendation, low-quality or very low-quality evidence | Benefits clearly outweigh risks and burdens or vice versa | Observational studies or case series |
2A | Weak recommendation, high-quality evidence | Benefits closely balanced with risks and burdens | RCTs without important limitations or overwhelming evidence from observational studies |
2B | Weak recommendation, moderate-quality evidence | Benefits closely balanced with risks and burdens | RCTs with important limitations or exceptionally strong evidence from observational studies |
2C | Weak recommendation, low-quality or very low-quality evidence | Uncertainty in the estimates of benefits, risks and burden; benefits, risk and burden may be closely balanced | Observational studies or case series |