Table 3 A profile of the animal research activities of Charles M. Tipton (1960–1998)
Animal research activities | ||||
|---|---|---|---|---|
A. | Experimental animals | |||
1. | Rodents (rats, both sexes and all studies (N = approximately 1,900) | |||
2. | Mongrel dogs (males only, cardiovascular and connective tissue studies (N = approximately 80) | |||
3. | Non-human primates (Galgo senegalenis, both sexes, systolic blood pressure and connective tissue studies (N = approximately 25) | |||
B. | Experimental animal studies | |||
1. | Development of exercise protocols and tests for dogs and rats | |||
2. | Investigations on the bradycardia of training | |||
a. | Normal | |||
b. | Diencephalon lesioned | |||
c. | Right and left unilateral vagectomized | |||
d. | Immunosympathectomized (IS) | |||
e. | Thyroidectomized | |||
f. | Adrenalectomized | |||
g. | Hypophysectomized | |||
h. | Isolated hearts (Langendorff) | |||
3. | Investigations on the influence of chronic exercise on systolic blood pressure | |||
a. | Normotensive, non-human primates | |||
b. | Normotensive , rats | |||
c. | Normotensive and aging (2 years) | |||
d. | Normotensive and a high fat diet | |||
e. | Normotensive and injections of desoxycortosterone acetate (DOCA) | |||
f. | Hypertensive because constriction of the renal artery | |||
g | Dahl salt sensitive hypertensive rats | |||
h | Dahl salt resistant hypertensive rats | |||
i | Spontaneously hypertensive rats (SHR) | |||
j | SHR and high calcium diets | |||
k | SHR and low calcium diets | |||
l | SHR and IS | |||
m | SHR and adrenal demedullation (DM) | |||
n | SHR, IS, and DM | |||
o | SHR and Strokeprone (SHR-SP) | |||
p | SHR-SP and static exercise | |||
q | SHR and post-exercise hypotension | |||
r | Hypophysectomizied (Hyphx) | |||
4. | Investigations on the influence of acute and chronic exercise on the oxygen transport system | |||
a. | Normal | |||
b. | SHR | |||
c. | Hyphx | |||
5. | Investigations on the influence of inactivity (immobilization) plus acute and chronic exercise on ligaments | |||
a. | Normal | |||
(1) | Aging | |||
(2) | Surgical repair | |||
b. | Hormonally deprived [Hyphx and thyroidectomized (Thyrx)] | |||
(1) | Surgical repair. | |||
(2) | Hyphx and replacement hormones [adrenal corticorticotrophin (ACTH), growth hormone (GH), interstitial-cell-stimulating hormone (ICSH), and thyroid-stimulating hormone (TSH). | |||
6. | Investigations on the influence of simulated microgravity on select physiological systems | |||
a. | Normal with both hindlimbs non-weight bearing | |||
b. | Normal with a single hindlimb non-weight bearing | |||
c | Hyphx with both hindlimbs non-weight bearing | |||