From: Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus
First author | Year | Organism | Muscle model | Hypoxia model | p(O 2 ) min (kPa) | Duration (d) | Marker | Change |
---|---|---|---|---|---|---|---|---|
Green [15] | 1992 | Human | vl | 4,300 m | 12.8 | 1 | Phosphofructokinase activity | ↓ |
Hexokinase activity | = | |||||||
Roberts [20] | 1996 | Human | vl | 4,300 m | 12.8 | 1 | Glucose oxidation | = |
Pastoris [29] | 1995 | Rat | gnm | 10% O2 | 10.1 | 3 | Hexokinase activity | = |
Phosphofructokinase activity | ↑ | |||||||
Lactate dehydrogenase activity | = | |||||||
Pyruvate kinase activity | ↓ | |||||||
Pastoris [29] | 1995 | Rat | sol | 10% O2 | 10.1 | 3 | Hexokinase activity | = |
Phosphofructokinase activity | ↓ | |||||||
Lactate dehydrogenase activity | = | |||||||
Pyruvate kinase activity | = | |||||||
Dutta [28] | 2009 | Rat | mix | 349 mmHg | 10.3 | 7 | Lactate dehydrogenase activity | ↑ |
Vigano [16] | 2008 | Human | vl | 4,559 m | 12.4 | 8 | Enolase levels | ↓ |
van Hall [21] | 2009 | Human | vl | 4,100 m | 13.1 | 14 | Lactate dehydrogenase activity | = |
De Palma [27] | 2007 | Rat | gnm | 10% O2 | 10.1 | 14 | β-enolase levels | ↓ |
Phosphoglyercomutase 2 levels | ↓ | |||||||
Pyruvate kinase levels | ↑ | |||||||
Triose phosphate isomerase levels | ↓ | |||||||
Young [22] | 1984 | Human | vl | 4,300 m | 12.8 | 18 | Hexokinase activity | = |
Lactate dehydrogenase activity | = | |||||||
Levett [18] | 2012 | Human | vl | 5,300 m | 11.3 | 19 | Hexokinase activity | = |
Roberts [30] | 1996 | Human | vl | 4,300 m | 12.8 | 21 | Glucose oxidation | ↑ |
Green [15] | 1992 | Human | vl | 4,300 m | 12.8 | 21 | Phosphofructokinase activity | ↓ |
Hexokinase activity | ↑ | |||||||
Daneshrad [24] | 2000 | Rat | sol | 10% O2 | 10.1 | 21 | Hexokinase activity | ↑ |
Lactate dehydrogenase activity | = | |||||||
Phosphofructokinase activity | = | |||||||
Pyruvate kinase levels | = | |||||||
Green [19] | 2000 | Human | vl | 6,194 m | 10.1 | 21 | Lactate dehydrogenase activity | ↑ |
Green [17] | 1989 | Human | vl | 8,848 m | 7.1 | 40 | Hexokinase activity | ↓ |
α-GPDH activity | = | |||||||
Lactate dehydrogenase activity | = | |||||||
Phosphofructokinase activity | = | |||||||
Pyruvate kinase levels | = | |||||||
van Hall [21] | 2009 | Human | vl | 4,100 m | 13.1 | 56 | Lactate dehydrogenase activity | = |
McClelland [25] | 2002 | Rat | sol | 4,300 m | 12.8 | 56 | Lactate dehydrogenase levels | = |
Monocarboxylate transporter 1 levels | = | |||||||
Monocarboxylate transporter 4 levels | ↓ | |||||||
McClelland [25] | 2002 | Rat | pla | 4,300 m | 12.8 | 56 | Lactate dehydrogenase levels | = |
Monocarboxylate transporter 1 levels | ↓ | |||||||
Monocarboxylate transporter 4 levels | ↓ | |||||||
McClelland [25] | 2002 | Rat | gnm | 4,300 m | 12.8 | 56 | Lactate dehydrogenase levels | = |
Monocarboxylate transporter 1 levels | = | |||||||
Monocarboxylate transporter 4 levels | = | |||||||
Abdelmalki [23] | 1996 | Rat | sol | 13% O2 | 13.1 | 64 | Lactate dehydrogenase activity | = |
Phosphofructokinase activity | ↑ | |||||||
Hexokinase activity | = | |||||||
Abdelmalki [23] | 1996 | Rat | pla | 13% O2 | 13.1 | 64 | Lactate dehydrogenase activity | = |
Phosphofructokinase activity | = | |||||||
Hexokinase activity | = | |||||||
Abdelmalki [23] | 1996 | Rat | rq | 13% O2 | 13.1 | 64 | Lactate dehydrogenase activity | = |
Phosphofructokinase activity | = | |||||||
Abdelmalki [23] | 1996 | Rat | wq | 13% O2 | 13.1 | 64 | Lactate dehydrogenase activity | = |
Phosphofructokinase activity | ↑ | |||||||
Levett [18] | 2012 | Human | vl | 8,848 m | 7.1 | 66 | Hexokinase activity | ↓ |
Ou [26] | 2004 | Rat | edl | 5,500 m | 11.0 | 90 | Lactate dehydrogenase activity | = |