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Hyperthermia exaggerates exercise-induced aggregation of blood platelets
Extreme Physiology & Medicine volume 4, Article number: A153 (2015)
Acute exposure to exertional exercise/heavy physical work often triggers cardiovascular events in which exercise-induced platelet aggregation, blood coagulation, and disruption in fibrinolysis may adversely affect atherothrombotic disease. Elevated body temperature, commonly accompanied with prolonged exercise, was suggested as an auxiliary factor for exercise-induced platelet aggregation . Recent studies also showed platelet hyperaggregation following firefighting activities combining heavy physical work and heat stress , . However, the influence of hyperthermia separated from physical exercise impact on platelet aggregation is unclear.
Twelve healthy men; age 22.8 (1.3) years and VO2max 56.8 (6.2) ml.kg-1.min-1, underwent three experimental trials: exercise hyperthermia (ExHT), passive hyperthermia (PaHT), and control exercise (CONT). Subjects performed a treadmill exercise at 60 % VO2max in the heat (35 °C, 50 % RH) until their rectal temperature (Tre) increased 1.5 °C above the resting baseline (ExHT) or performed a control exercise at the same intensity and duration according to ExHT in a cooler condition (23 °C, 50 % RH) (CONT). In PaHT, subjects were passively heated using a water garment (45 °C) in the heat (45 °C, 50 % RH) until Tre increased 1.5 °C above baseline. Platelet aggregation was assessed from antecubital venous blood collected during baseline (Base), end-trial (End), and again following 1 hour of passive recovery (Rec) (23 °C, 50 % RH), using a platelet function analyser providing a closure time (CT: second) through an in-vitro simulation of platelet adhesion, activation, and aggregation. Decreased CT is an indicative of increased platelet aggregation. Dependent variables were analysed using a two-way repeated measures ANOVA.
Under the study conditions, Tre (F = 13.2, p<0.001) and skin temperature (F = 97.3, p<0.001) increased significantly in ExHT and PaHT compared to CONT, whereas heart rate was significantly higher in ExHT and CONT compared to PaHT (F = 40.0, p<0.001). CT in exposure to Collagen/ADP showed a decreasing trend over time in ExHT and PaHT and significantly differed from CONT at Rec (F = 7.6, p = 0.008). CT in exposure to Collagen/Epinephrine showed a similar response to Collagen/ADP, but did not significantly differ among conditions (F = 3.5, p = 0.075), though CT in ExHT significantly decreased at End compared to CT in CONT (p = 0.046).
Moderate exercise in the heat (ExHT) significantly elevated platelet aggregation as indicated by decreased CT whereas CT was not altered in non-hyperthermia exercise condition (CONT). PaHT showed an overall decreasing trend of CT toward End and Rec, but its impact on platelet aggregation was not significant in response to C/EPI in this study.
It was concluded that hyperthermia exaggerates exercise-induced platelet aggregation as an auxiliary factor, but the effect of hyperthermia alone on platelet aggregation in young, healthy subjects is minimal. Further research is warranted to investigate a physiological mechanism responsible for hyperthermia induced-platelet hyperreactivity.
The findings and conclusions of this abstract are those of the authors and do not necessarily reflect the views of the National Institute for Occupational Safety and Health.
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Kim, JH., Wu, T., Roberge, R. et al. Hyperthermia exaggerates exercise-induced aggregation of blood platelets. Extrem Physiol Med 4 (Suppl 1), A153 (2015). https://doi.org/10.1186/2046-7648-4-S1-A153
- Platelet Aggregation
- Physical Work
- Control Exercise
- Passive Recovery
- Auxiliary Factor